Jose Russo
Fox Chase Cancer Center-Temple Health, USA
Title: PThe molecular mechanism of the dual effect of pregnancy and lactation in risk and prevention of breast cancer
Biography
Biography: Jose Russo
Abstract
We have studied the genomic profile of nulliparous and parous women in the premenopausal and postmenopausal period and found genes that are activated only during the first five years after pregnancy and lactation that may contribute to the increased risk of breast cancer experienced by certain women after pregnancy. At the same time, we have confirmed that pregnancy and lactation induces a long lasting genomic signature that starts after pregnancy and explains preventive effect. The molecular mechanism related to prevention is based on chromatin remodeling process.