Day 2 :
Fox Chase Cancer Center-Temple Health, USA
Keynote: PThe molecular mechanism of the dual effect of pregnancy and lactation in risk and prevention of breast cancer
Time : 14:05-14:35
Jose Russo, MD is a Senior Member and Director of the Irma H Russo, MD Breast Cancer Research Laboratory, Director of the Breast Cancer and The Environment Research Center at the Fox Chase Cancer Center and Professor of Biochemistry in Temple Medical School and Adjunct Professor of Pathology and Cell Biology at Jefferson Medical School in Philadelphia, Pennsylvania. He has authored more than 400 publications; 13 books and is a member of several editorial boards of scientific journals. He has received numerous research awards from the National Cancer Institute- National Institute of Health (NIH) of the United States, the American Cancer Society and the Department of Defence for his original research on breast cancer. For the last 40 years, he has been an active member of the NIH peer review system and has served as a special reviewer for the American Cancer Society, National Science Foundation, Department of Defence and Veteran Affairs. He has trained 55 PhD and MD investigators in cancer research. His interest has a broad base, but with a focused goal: to understand the mechanisms that control the susceptibility of the breast epithelium to undergo neoplastic transformation; to identify markers of susceptibility, and; to develop strategies for breast cancer prevention.
We have studied the genomic profile of nulliparous and parous women in the premenopausal and postmenopausal period and found genes that are activated only during the first five years after pregnancy and lactation that may contribute to the increased risk of breast cancer experienced by certain women after pregnancy. At the same time, we have confirmed that pregnancy and lactation induces a long lasting genomic signature that starts after pregnancy and explains preventive effect. The molecular mechanism related to prevention is based on chromatin remodeling process.
Ohio State University College of Medicine
Time : 14:05-14:35
Shahid Sheikh is an Associate Professor of Clinical Pediatrics at The Ohio State University College of Medicine. Currently, he is working at divisions of Allergy/Immunology and Pediatric Pulmonary Medicine in Department of Pediatrics at Nationwide Children’s Hospital, Columbus Ohio. His major interests are Pediatric Asthma and Cystic Fibrosis. He has published about 50 papers in peer-reviewed journals and has been serving as co-editor in editorial board of seven peer-reviewed journals.rn
Asthma is the most common chronic childhood disease with increasing prevalence especially in urban minority communities. It is important to identify asthma early in risk groups such as children. In 2011, the lifetime asthma prevalence among children ages 5 to 14 years in the United States was 15.6%. Studies have reported that estimates of the prevalence of undiagnosed asthma among children in the United States were between 14%-17%. Young children with episodes of wheezing, night time cough and/or exercise related limitations are always a dilemma as parents are never certain if their children have asthma or will develop asthma at a later age. It is estimated that about 30% of preschool children with wheezing may have underlying asthma and most of children with asthma develop symptoms in pre-school years. We will discuss difficulties in making a diagnosis of asthma in early age. How can we simplify do the diagnosis so that early therapies can be initiated to decrease morbidity will be discussed.